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Drosophila melanogaster continua mosca da fruta
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05082012
Drosophila melanogaster continua mosca da fruta
Sábado, Maio 12, 2012
Genome-wide analysis of a long-term evolution experiment with Drosophila
Nature
467,
587–590
(30 September 2010)
doi:10.1038/nature09352
Received
05 April 2010
Accepted
15 July 2010
Published online
15 September 2010
Drosophila melanogaster - The Economist
Abstract
Experimental evolution systems allow the genomic study of adaptation, and so far this has been done primarily in asexual systems with small genomes, such as bacteria and yeast1, 2, 3. Here we present whole-genome resequencing data from Drosophila melanogaster populations that have experienced over 600 generations of laboratory selection for accelerated development. Flies in these selected populations develop from egg to adult ~20% faster than flies of ancestral control populations, and have evolved a number of other correlated phenotypes. On the basis of 688,520 intermediate-frequency, high-quality single nucleotide polymorphisms, we identify several dozen genomic regions that show strong allele frequency differentiation between a pooled sample of five replicate populations selected for accelerated development and pooled controls. On the basis of resequencing data from a single replicate population with accelerated development, as well as single nucleotide polymorphism data from individual flies from each replicate population, we infer little allele frequency differentiation between replicate populations within a selection treatment. Signatures of selection are qualitatively different than what has been observed in asexual species; in our sexual populations, adaptation is not associated with ‘classic’ sweeps whereby newly arising, unconditionally advantageous mutations become fixed. More parsimonious explanations include ‘incomplete’ sweep models, in which mutations have not had enough time to fix, and ‘soft’ sweep models, in which selection acts on pre-existing, common genetic variants. We conclude that, at least for life history characters such as development time, unconditionally advantageous alleles rarely arise, are associated with small net fitness gains or cannot fix because selection coefficients change over time.
+++++
Paper freely available here/Artigo disponível gratis aqui.
You might also like/Você pode gostar também de:
SPCD (Só pra contrariar Darwin): a Drosophila melanogaster continua mosquinha da fruta...
Genome-wide analysis of a long-term evolution experiment with Drosophila
- Molly K. Burke,
- Joseph P. Dunham,
- Parvin Shahrestani,
- Kevin R. Thornton,
- Michael R. Rose
- & Anthony D. Long
- Affiliations
- Contributions
- Corresponding authors
Nature
467,
587–590
(30 September 2010)
doi:10.1038/nature09352
Received
05 April 2010
Accepted
15 July 2010
Published online
15 September 2010
Drosophila melanogaster - The Economist
Abstract
Experimental evolution systems allow the genomic study of adaptation, and so far this has been done primarily in asexual systems with small genomes, such as bacteria and yeast1, 2, 3. Here we present whole-genome resequencing data from Drosophila melanogaster populations that have experienced over 600 generations of laboratory selection for accelerated development. Flies in these selected populations develop from egg to adult ~20% faster than flies of ancestral control populations, and have evolved a number of other correlated phenotypes. On the basis of 688,520 intermediate-frequency, high-quality single nucleotide polymorphisms, we identify several dozen genomic regions that show strong allele frequency differentiation between a pooled sample of five replicate populations selected for accelerated development and pooled controls. On the basis of resequencing data from a single replicate population with accelerated development, as well as single nucleotide polymorphism data from individual flies from each replicate population, we infer little allele frequency differentiation between replicate populations within a selection treatment. Signatures of selection are qualitatively different than what has been observed in asexual species; in our sexual populations, adaptation is not associated with ‘classic’ sweeps whereby newly arising, unconditionally advantageous mutations become fixed. More parsimonious explanations include ‘incomplete’ sweep models, in which mutations have not had enough time to fix, and ‘soft’ sweep models, in which selection acts on pre-existing, common genetic variants. We conclude that, at least for life history characters such as development time, unconditionally advantageous alleles rarely arise, are associated with small net fitness gains or cannot fix because selection coefficients change over time.
+++++
Paper freely available here/Artigo disponível gratis aqui.
You might also like/Você pode gostar também de:
- Novos genes derivados de DNA não codificante em Drosophila melanogaster
- Desenvolvimento da mosquinha de fruta, célula por célula: mero acaso, fortuita necessidade ou design inteligente?
- O grande quadro dos cromossomos revela: Darwin é geneticamente aparentado com mosquinha de fruta, banana...
- Darwin errou feio fundamentalmente sobre a seleção natural: a evolução é um processo guiado e com previsão
SPCD (Só pra contrariar Darwin): a Drosophila melanogaster continua mosquinha da fruta...
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